Models used in LongQT

Brief description of each model, note the initial publication and important papers since then that have referenced it

Canine Ventricular & Canine Ventricular Border Zone (Hund-Rudy 2009)

Christensen, M. D., Dun, W., Boyden, P. A., Anderson, M. E., Mohler, P. J., & Hund, T. J. (2009). Oxidized calmodulin kinase II regulates conduction following myocardial infarction: A computational analysis. PLoS Computational Biology, 5(12). https://doi.org/10.1371/journal.pcbi.1000583

Human Atrial (Courtemanche 1998)

Courtemanche, M., Ramirez, R. J., & Nattel, S. (1998). Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. The American Journal of Physiology, 275(1 Pt 2), H301-21. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9688927

Human Atrial (Grandi 2011)

Grandi, E., Pandit, S. V., Voigt, N., Workman, A. J., Dobrev, D., Jalife, J., & Bers, D. M. (2011). Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation. Circulation Research, 109(9), 1055–1066. https://doi.org/10.1161/CIRCRESAHA.111.253955

GpbAtrialOnal17

Onal, B., Gratz, D., & Hund, T. J. (2017). Ca 2+ /calmodulin kinase II-dependent regulation of atrial myocyte late Na+ current, Ca 2+ cycling and excitability: a mathematical modeling study. American Journal of Physiology - Heart and Circulatory Physiology, ajpheart.00185.2017. https://doi.org/10.1152/ajpheart.00185.2017

Human Ventricular (Grandi 10)

Grandi, E., Pasqualini, F. S., & Bers, D. M. (2009). A novel computational model of the human ventricular action potential and Ca transient. https://doi.org/10.1016/j.yjmcc.2009.09.019

Human Ventricular (Ten Tusscher 2004)

ten Tusscher, K. H. W. J., Noble, D., Noble, P. J., & Panfilov, A. V. (2004). A model for human ventricular tissue. American Journal of Physiology. Heart and Circulatory Physiology, 286(4), H1573-89. https://doi.org/10.1152/ajpheart.00794.2003

Human Ventricular Endocardium, Epicardium, Mid Myocardial (O'Hara-Rudy 2011)

O ’hara, T., Szló Virá G, L., Varró, A. S., & Rudy, Y. (2011). Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation. PLoS Comput Biol, 7(5), 1002061–1002302. https://doi.org/10.1371/journal.pcbi.1002061

Mammalian Ventricular (Faber-Rudy 2000)

Faber, Gregory M., and Yoram Rudy. “Action Potential and Contractility Changes [Na+](i) Overloaded Cardiac Myocytes: A Simulation Study.” Biophysical Journal, vol. 78, no. 5, Elsevier, 2000, pp. 2392–404, doi:10.1016/S0006-3495(00)76783-X.

Mouse Sinus Node (Kharche 2011)

Kharche, Sanjay, et al. “A Mathematical Model of Action Potentials of Mouse Sinoatrial Node Cells with Molecular Bases.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 301, no. 3, Sept. 2011, pp. H945–63, doi:10.1152/ajpheart.00143.2010.

Mouse Ventricular (Bondarenko 2004)

Bondarenko, V. E. “Computer Model of Action Potential of Mouse Ventricular Myocytes.” AJP: Heart and Circulatory Physiology, vol. 287, no. 3, 2004, pp. H1378–403, doi:10.1152/ajpheart.00185.2003.

Rabbit Sinus Node (Kurata 2008)

Kurata, Y., Matsuda, H., Hisatome, I., & Shibamoto, T. (2008). Regional difference in dynamical property of sinoatrial node pacemaking: Role of Na+channel current. Biophysical Journal, 95(2), 951–977. https://doi.org/10.1529/biophysj.107.112854

Grid

paper detailing the 2D grid function

Inexcitable Cell

paper that used this cell